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Auflistung Nach Schlagwort "Meta-Analysis as Topic"

Anzeige der Dokumente 1-20 von 21

    • Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus 

      Medina-Gomez C., Kemp J.P., Dimou N.L., Kreiner E., Chesi A., Zemel B.S., Bønnelykke K., Boer C.G., Ahluwalia T.S., Bisgaard H., Evangelou E., Heppe D.H.M., Bonewald L.F., Gorski J.P., Ghanbari M., Demissie S., Duque G., Maurano M.T., Kiel D.P., Hsu Y.-H., Van Der Eerden B.C.J., Ackert-Bicknell C., Reppe S., Gautvik K.M., Raastad T., Karasik D., Van De Peppel J., Jaddoe V.W.V., Uitterlinden A.G., Tobias J.H., Grant S.F.A., Bagos P.G., Evans D.M., Rivadeneira F. (2017)
      Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS ...

    • Characteristics of the Protocols Used in Electrical Pulse Stimulation of Cultured Cells for Mimicking In Vivo Exercise: A Systematic Review, Meta-Analysis, and Meta-Regression 

      Nintou E., Karligiotou E., Vliora M., Ioannou L.G., Flouris A.D. (2022)
      While exercise benefits a wide spectrum of diseases and affects most tissues and organs, many aspects of its underlying mechanistic effects remain unsolved. In vitro exercise, mimicking neuronal signals leading to muscle ...

    • DE-PASS Best Evidence Statement (BESt): Modifiable determinants of physical activity and sedentary behaviour in children and adolescents aged 5-19 years-a protocol for systematic review and meta-analysis 

      Khudair M., Marcuzzi A., Ng K., Tempest G.D., Bartoš F., Peric R., Maier M., Beccia F., Boccia S., Brandes M., Cardon G., Carlin A., Castagna C., Chaabene H., Chalkley A., Ciaccioni S., Cieślińska-Wider J., Ingien - V., Cortis C., Corvino C., De Geus E.J.C., Di Baldassarre A., Di Credico A., Drid P., Fernández Tarazaga R.M., Gallè F., García Sánchez E., Gebremariam M., Ghinassi B., Goudas M., Hayes G., Honorio S., Izzicupo P., Jahre H., Jelsma J., Juric P., Kolovelonis A., Kongsvold A., Kouidi E., Mansergh F., Masanovic B., Mekonnen T., Mork P.J., Murphy M., O'Hara K., Torun A.O., Palumbo F., Popovic S., Prieske O., Puharic Z., Ribeiro J.C., Rumbold P.L.S., Sandu P., Sorić M., Stavnsbo M., Syrmpas I., Van Der Ploeg H.P., Van Hoye A., Vilela S., Woods C., Wunsch K., Caprinica L., Macdonncha C., Ling F.C.M. (2022)
      Introduction Physical activity among children and adolescents remains insufficient, despite the substantial efforts made by researchers and policymakers. Identifying and furthering our understanding of potential modifiable ...

    • Effect of physical activity interventions on quality of life in older adults: A protocol for systematic review and meta-analysis 

      Lamberti N., Manfredini F., Babjaková J., Gallè F., Medijainen K., Karatzaferi C., Pavlova I., Netz Y., López-Soto P.J. (2022)
      Introduction: Quality of life (QoL) has been acknowledged as a fundamental concept in the field of health and is favorably improved by physical activity (PA). This systematic review aims to assess the benefits and harms ...

    • Effective strategies for childhood obesity prevention via school based, family involved interventions: A critical review for the development of the Feel4Diabetes-study school based component 

      Lambrinou C.-P., Androutsos O., Karaglani E., Cardon G., Huys N., Wikström K., Kivelä J., Ko W., Karuranga E., Tsochev K., Iotova V., Dimova R., De Miguel-Etayo P., Gonzalez-Gil E.Mª., Tamás H., Jancsó Z., Liatis S., Makrilakis K., Manios Y., Cardon G., Lindström J., Schwarz P., Makrilakis K., Annemans L., Garamendi I., Karatzi K., Androutsos O., Moschonis G., Kanellakis S., Mavrogianni C., Tsoutsoulopoulou K., Katsarou C., Karaglani E., Qira I., Skoufas E., Maragkopoulou K., Tsiafitsa A., Sotiropoulou I., Tsolakos M., Argyri E., Nikolaou M., Vampouli E.-A., Filippou C., Apergi K., Filippou A., Katerina G., Dimitriadis E., Lindström J., Laatikainen T., Wikström K., Hovi P., Kivelä J., Valve P., Levälahti E., Virtanen E., Cardon G., Van Stappen V., Huys N., Annemans L., Willems R., Shadid S., Schwarz P., Timpel P., Makrilakis K., Liatis S., Dafoulas G., Lambrinou C.-P., Giannopoulou A., Rabemananjara L., De Sabata M.S., Ko W., Garamendi I., Moreno L., Civeira F., Bueno G., De Miguel-Etayo P., Miguel-Berges M.L., Giménez-Legarre N., Flores-Barrantes P., Ayala-Marín A.M., Seral-Cortés M., Baila-Rueda L., Cenarro A., Jarauta E., Mateo-Gallego R., Tankova T., Usheva N., Tsochev K., Chakarova N., Galcheva S., Dimova R., Bocheva Y., Radkova Z., Marinova V., Bazdarska Y., Stefanova T., Rurik I., Ungvari T., Jancsó Z., Nánási A., Kolozsvári L., Semánova C., Bíró É., Antal E., Radó S., Martinez R., Tong M. (2020)
      Background: Although there are many interventions targeting childhood obesity prevention, only few have demonstrated positive results. The current review aimed to gather and evaluate available school-based intervention ...

    • Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia 

      Hackinger S., Prins B., Mamakou V., Zengini E., Marouli E., Brčić L., Serafetinidis I., Lamnissou K., Kontaxakis V., Dedoussis G., Gonidakis F., Thanopoulou A., Tentolouris N., Tsezou A., Zeggini E. (2018)
      The epidemiologic link between schizophrenia (SCZ) and type 2 diabetes (T2D) remains poorly understood. Here, we investigate the presence and extent of a shared genetic background between SCZ and T2D using genome-wide ...

    • GWAR: Robust analysis and meta-analysis of genome-wide association studies 

      Dimou N.L., Tsirigos K.D., Elofsson A., Bagos P.G. (2017)
      Motivation: In the context of genome-wide association studies (GWAS), there is a variety of statistical techniques in order to conduct the analysis, but, in most cases, the underlying genetic model is usually unknown. Under ...

    • International consensus on the diagnosis and management of pediatric patients with hereditary angioedema with C1 inhibitor deficiency 

      Farkas H., Martinez-Saguer I., Bork K., Bowen T., Craig T., Frank M., Germenis A.E., Grumach A.S., Luczay A., Varga L., Zanichelli A., HAWK, Aberer W., Andrejevic S., Aygoeren-Pürsün E., Banerji A., Bara N.-A., Bas M., Bernstein J., Betschel S., Björkander J., Boccon-Gibod I., Bouillet L., Bova M., Boysen H.H., Branco-Ferreira M., Bygum A., Caballero T., Cancian M., Castaldo A., Christiansen S., Cicardi M., Drouet C., Fabiani J., Gompels M., Gonzalez-Quevedo M.T., Gooi J., Gower R., Gökmen N.M., Grivcheva-Panovska V., Guilarte M., Gülbahar O., Hack E., Hakl R., Harmat G., Jeseňák M., Jolles S., Kaplan A., Katelaris C., Kosnik M., Kőhalmi K.V., Leibovich I., Levi M., Li H., Longhurst H.J., Lumry W., Magerl M., Malbran A., Martin L., Maurer M., Mihály E., Moldovan D., Murdjeva M., Nagy I.B., Nielsen E.W., Nieto S., Nordenfelt P., Obtulowitzc K., Pedrosa M., Porębski G., Prior N., Reshef A., Riedl M.A., Rosenkranz B., Schmid-Grendelmeier P., Péter S., Speletas M., Staevska M., Stobiecki M., Triggiani M., Veszeli N., Wuillemin W., Xiang Z.Y., Yamamoto B., Zuraw B. (2017)
      Background: The consensus documents published to date on hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) have focused on adult patients. Many of the previous recommendations have not been adapted to pediatric ...

    • Interventions to improve cardiopulmonary resuscitation: A review of meta-analyses and future agenda 

      Chalkias A., Ioannidis J.P.A. (2019)
      [No abstract available]

    • Lack of association between TREM2 rs75932628 variant and amyotrophic lateral sclerosis 

      Siokas V., Aloizou A.-M., Liampas I., Tsouris Z., Mentis A.-F.A., Nasios G., Papadimitriou D., Bogdanos D.P., Hadjigeorgiou G.M., Dardiotis E. (2021)
      Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease. Inflammatory processes are among the mechanisms that are implicated in ALS pathogenesis. The TREM2 rs75932628 T variant may influence the ...

    • Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study 

      Elbaz, A.; Nelson, L. M.; Payami, H.; Ioannidis, J. P.; Fiske, B. K.; Annesi, G.; Carmine Belin, A.; Factor, S. A.; Ferrarese, C.; Hadjigeorgiou, G. M.; Higgins, D. S.; Kawakami, H.; Krüger, R.; Marder, K. S.; Mayeux, R. P.; Mellick, G. D.; Nutt, J. G.; Ritz, B.; Samii, A.; Tanner, C. M.; Van Broeckhoven, C.; Van Den Eeden, S. K.; Wirdefeldt, K.; Zabetian, C. P.; Dehem, M.; Montimurro, J. S.; Southwick, A.; Myers, R. M.; Trikalinos, T. A. (2006)
      Background: A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale replication studies were largely non-confirmatory, but a ...

    • A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease 

      Krüger, R.; Sharma, M.; Riess, O.; Gasser, T.; Van Broeckhoven, C.; Theuns, J.; Aasly, J.; Annesi, G.; Bentivoglio, A. R.; Brice, A.; Djarmati, A.; Elbaz, A.; Farrer, M.; Ferrarese, C.; Gibson, J. M.; Hadjigeorgiou, G. M.; Hattori, N.; Ioannidis, J. P. A.; Jasinska-Myga, B.; Klein, C.; Lambert, J. C.; Lesage, S.; Lin, J. J.; Lynch, T.; Mellick, G. D.; de Nigris, F.; Opala, G.; Prigione, A.; Quattrone, A.; Ross, O. A.; Satake, W.; Silburn, P. A.; Tan, E. K.; Toda, T.; Tomiyama, H.; Wirdefeldt, K.; Wszolek, Z.; Xiromerisiou, G.; Maraganore, D. M. (2011)
      High-profile studies have provided conflicting results regarding the involvement of the Omi/HtrA2 gene in Parkinson's disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common ...

    • Meta-analysis in Stata using gllamm 

      Bagos P.G. (2015)
      There are several user-written programs for performing meta-analysis in Stata (Stata Statistical Software: College Station, TX: Stata Corp LP). These include metan, metareg, mvmeta, and glst. However, there are several ...

    • Meta-Analysis Methods of Diagnostic Test Accuracy Studies 

      Dimou N., Bagos P. (2022)
      Meta-analytic techniques are used to combine the results of different studies that have evaluated the accuracy of diagnostic tests. In this article, we present univariate and multivariate meta-analysis methods for a single ...

    • A multivariate method for meta-analysis and comparison of diagnostic tests 

      Dimou N.L., Adam M., Bagos P.G. (2016)
      We present here an extension of the classic bivariate random effects meta-analysis for the log-transformed sensitivity and specificity that can be applied for two or more diagnostic tests. The advantage of this method is ...

    • Multivariate methods for meta-analysis of genetic association studies 

      Dimou N.L., Pantavou K.G., Braliou G.G., Bagos P.G. (2018)
      Multivariate meta-analysis of genetic association studies and genome-wide association studies has received a remarkable attention as it improves the precision of the analysis. Here, we review, summarize and present in a ...

    • A new method for synthesizing test accuracy data outperformed the bivariate method 

      Furuya-Kanamori L., Kostoulas P., Doi S.A.R. (2021)
      Objectives: This study outlines the development of a new method (split component synthesis; SCS) for meta-analysis of diagnostic accuracy studies and assesses its performance against the commonly used bivariate random ...

    • Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration 

      Ratnapriya, R.; Zhan, X.; Fariss, R. N.; Branham, K. E.; Zipprer, D.; Chakarova, C. F.; Sergeev, Y. V.; Campos, M. M.; Othman, M.; Friedman, J. S.; Maminishkis, A.; Waseem, N. H.; Brooks, M.; Rajasimha, H. K.; Edwards, A. O.; Lotery, A.; Klein, B. E.; Truitt, B. J.; Li, B.; Schaumberg, D. A.; Morgan, D. J.; Morrison, M. A.; Souied, E.; Tsironi, E. E.; Grassmann, F.; Fishman, G. A.; Silvestri, G.; Scholl, H. P. N.; Kim, I. K.; Ramke, J.; Tuo, J.; Merriam, J. E.; Merriam, J. C.; Park, K. H.; Olson, L. M.; Farrer, L. A.; Johnson, M. P.; Peachey, N. S.; Lathrop, M.; Baron, R. V.; Igo, R. P.; Klein, R.; Hagstrom, S. A.; Kamatani, Y.; Martin, T. M.; Jiang, Y.; Conley, Y.; Sahel, J. A.; Zack, D. J.; Chan, C. C.; Pericak-Vance, M. A.; Jacobson, S. G.; Gorin, M. B.; Klein, M. L.; Allikmets, R.; Iyengar, S. K.; Weber, B. H.; Haines, J. L.; Léveillard, T.; Deangelis, M. M.; Stambolian, D.; Weeks, D. E.; Bhattacharya, S. E.; Chew, E. Y.; Heckenlively, J. R.; Abecasis, G. R.; Swaroop, A. (2014)
      Neurodegenerative diseases affecting the macula constitute amajor cause of incurable vision loss and exhibit considerable clinical and genetic heterogeneity, from early-onset monogenic disease to multifactorial lateonset ...

    • Replication study of GWAS risk loci in Greek multiple sclerosis patients 

      Hadjigeorgiou G.M., Kountra P.-M., Koutsis G., Tsimourtou V., Siokas V., Dardioti M., Rikos D., Marogianni C., Aloizou A.-M., Karadima G., Ralli S., Grigoriadis N., Bogdanos D., Panas M., Dardiotis E. (2019)
      Objectives: To validate in an ethnically homogeneous Greek multiple sclerosis (MS) cohort, genetic risk factors for the disease, identified through a number of previous multi-ethnic genome-wide association studies (GWAS). ...

    • Seven new loci associated with age-related macular degeneration 

      Fritsche, L. G.; Chen, W.; Schu, M.; Yaspan, B. L.; Yu, Y.; Thorleifsson, G.; Zack, D. J.; Arakawa, S.; Cipriani, V.; Ripke, S.; Igo, R. P.; Buitendijk, G. H. S.; Sim, X.; Weeks, D. E.; Guymer, R. H.; Merriam, J. E.; Francis, P. J.; Hannum, G.; Agarwal, A.; Armbrecht, A. M.; Audo, I.; Aung, T.; Barile, G. R.; Benchaboune, M.; Bird, A. C.; Bishop, P. N.; Branham, K. E.; Brooks, M.; Brucker, A. J.; Cade, W. H.; Cain, M. S.; Campochiaro, P. A.; Chan, C. C.; Cheng, C. Y.; Chew, E. Y.; Chin, K. A.; Chowers, I.; Clayton, D. G.; Cojocaru, R.; Conley, Y. P.; Cornes, B. K.; Daly, M. J.; Dhillon, B.; Edwards, A. O.; Evangelou, E.; Fagerness, J.; Ferreyra, H. A.; Friedman, J. S.; Geirsdottir, A.; George, R. J.; Gieger, C.; Gupta, N.; Hagstrom, S. A.; Harding, S. P.; Haritoglou, C.; Heckenlively, J. R.; Holz, F. G.; Hughes, G.; Ioannidis, J. P. A.; Ishibashi, T.; Joseph, P.; Jun, G.; Kamatani, Y.; Katsanis, N.; N Keilhauer, C.; Khan, J. C.; Kim, I. K.; Kiyohara, Y.; Klein, B. E. K.; Klein, R.; Kovach, J. L.; Kozak, I.; Lee, C. J.; Lee, K. E.; Lichtner, P.; Lotery, A. J.; Meitinger, T.; Mitchell, P.; Mohand-Saïd, S.; Moore, A. T.; Morgan, D. J.; Morrison, M. A.; Myers, C. E.; Naj, A. C.; Nakamura, Y.; Okada, Y.; Orlin, A.; Ortube, M. C.; Othman, M. I.; Pappas, C.; Park, K. H.; Pauer, G. J. T.; Peachey, N. S.; Poch, O.; Priya, R. R.; Reynolds, R.; Richardson, A. J.; Ripp, R.; Rudolph, G.; Ryu, E.; Sahel, J. A.; Schaumberg, D. A.; Scholl, H. P. N.; Schwartz, S. G.; Scott, W. K.; Shahid, H.; Sigurdsson, H.; Silvestri, G.; Sivakumaran, T. A.; Smith, R. T.; Sobrin, L.; Souied, E. H.; Stambolian, D. E.; Stefansson, H.; Sturgill-Short, G. M.; Takahashi, A.; Tosakulwong, N.; Truitt, B. J.; Tsironi, E. E.; Uitterlinden, A. G.; Van Duijn, C. M.; Vijaya, L.; Vingerling, J. R.; Vithana, E. N.; Webster, A. R.; Wichmann, H. E.; Winkler, T. W.; Wong, T. Y.; Wright, A. F.; Zelenika, D.; Zhang, M.; Zhao, L.; Zhang, K.; Klein, M. L.; Hageman, G. S.; Lathrop, G. M.; Stefansson, K.; Allikmets, R.; Baird, P. N.; Gorin, M. B.; Wang, J. J.; Klaver, C. C. W.; Seddon, J. M.; Pericak-Vance, M. A.; Iyengar, S. K.; Yates, J. R. W.; Swaroop, A.; Weber, B. H. F.; Kubo, M.; Deangelis, M. M.; Léveillard, T.; Thorsteinsdottir, U.; Haines, J. L.; Farrer, L. A.; Heid, I. M.; Abecasis, G. R. (2013)
      Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association ...